Tumour
Conditions
Interventions
Observation group:NA
Sponsors
Shanghai No. 6 Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Confirmed by histology or cytology as bone giant cell tumor, multiple myeloma or solid tumor bone metastasis, solid tumor Including but not limited to lung cancer, breast cancer, bowel cancer, liver cancer, esophageal cancer, etc., and desulsuman antibody is required Perform treatment; 2.Receive imaging examinations such as computer tomography (CT), magnetic resonance imaging (MRI), X-ray, etc., and prompt to There is 1 less bone metastasis or characteristic osteolytic lesions; 3.Age>=18 years old; 4.Assessment of physical fitness status of Eastern Cooperative Oncology Group (ECOG) It is divided into 0-2 points; 5.The estimated survival time is>=6 months.
Exclusion criteria
Exclusion criteria: 1.Severe heart, liver, kidney, lung and brain insufficiency; 2.Pregnant women, breastfeeding women; 3.Patients who are allergic to research drugs or are prohibited from using research drugs in other instructions; 4.Past or currently suffering from osteomyelitis of jaw or osteonecrosis of jaw; in active period, oral hand needs to be performed dental or jaw disease; dental or oral surgery wounds have not healed; 5.Those with incomplete clinical data.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Types and timing of bone related events (SRE) within 6 months.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Type and time of occurrence of bone related events (SRE) within 3 months.;At 3 or 6 months of treatment, urinary type I collagen cross-linked N-terminal peptide (uNTx/uCr) adjusted for urinary creatinine (uCr) percentage of change relative to baseline.;At 3 or 6 months of treatment, compared with baseline serum calcium, phosphorus ion concentrations and serum alkaline phosphatase (ALP) level.;Bone mineral density compared to baseline at 6 months of treatment.;Median time from first to second SRE of the same type during the study period;Bone pain worsens within 6 months;Types and severity of adverse reactions; | — |
Countries
China
Contacts
Public ContactYang Qingcheng
Shanghai No. 6 Hospital
Outcome results
None listed