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Exploring intergenerational transmission of trait anxiety in adolescents: An epigenetic investigation and early identification of high-risk families

Exploring intergenerational transmission of trait anxiety in adolescents: An epigenetic investigation and early identification of high-risk families

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500097282
Enrollment
Unknown
Registered
2025-02-17
Start date
2025-03-01
Completion date
Unknown
Last updated
2025-02-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

adolescent Emotional Disorders

Interventions

Healthy Control:none
High Trait Anxiety Group (Case):none

Sponsors

Beijing Huilongguan Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
13 Years to 18 Years

Inclusion criteria

Inclusion criteria: High Trait Anxiety Group 1. Han Chinese adolescents aged 13-18, with no age limit for parents; 2. Diagnosed with depressive disorder by at least two senior clinical physicians with years of experience, according to DSM-5 criteria. The diagnosis will be further verified through interviews with both the patient and their guardian using the Chinese version of the School-Aged Children’s Emotional Disorders and Schizophrenia Questionnaire – Lifetime Edition (K-SADS-PL DSM-5). Additionally, based on the T-AI score in the STAI assessment, 50 boys with T-AI > 56 and 50 girls with T-AI > 57 will be recruited, maintaining a 1:1 gender ratio; 3. Patients voluntarily participate in the study, and their family members agree and sign the informed consent form. Healthy Control Group 1. Han Chinese adolescents aged 13-18, with no age limit for parents; 2. Based on the T-AI score in the STAI assessment, 50 boys with T-AI = 56 and 50 girls with T-AI = 57 will be recruited, maintaining a 1:1 gender ratio; 3. Patients voluntarily participate in the study, and their family members agree and sign the informed consent form.

Exclusion criteria

Exclusion criteria: High Trait Anxiety Group 1. Diagnosis of any psychiatric disorder other than adolescent emotional disorders; 2. History of epilepsy, head trauma, neurological diseases, or similar conditions; 3. Substance or drug abuse; 4. Presence of any other severe physical diseases; 5. History of long-term medication use. Healthy Control Group 1. Diagnosis of any psychiatric disorder; 2. History of epilepsy, head trauma, neurological diseases, or similar conditions; 3. Substance or drug abuse; 4. Presence of any other severe physical diseases; 5. History of long-term medication use.

Design outcomes

Primary

MeasureTime frame
trait anxiety score;HAMA score;Parent child relationship;

Secondary

MeasureTime frame
HAMD score;

Countries

China

Contacts

Public ContactSu Yi

Beijing Huilongguan Hospital

syremember@126.com+86 10 8302 4429

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026