None
Conditions
Interventions
OR Group:Remimazolam and oxycodone are used during anesthesia
OC Group:Ciprofol and oxycodone are used during anesthesia
NC Group:Ciprofol is used during anesthesia
NR Group:Remimazolam is used during anesthesia
Sponsors
The First Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: The subjects of this study were elderly patients aged 60-80 years, ASA ?-?, with body mass index of 16-30 kg/m2, undergoing thoracoscopic surgery under general anesthesia, with operation time <=2 hours, and undergoing postoperative PCIA.
Exclusion criteria
Exclusion criteria: Exclusion criteria: patients with a history of chronic pain or opioid abuse before surgery, drug and/or alcohol abuse within the past 3 months, cognitive impairment or language impairment with poor communication, schizophrenia and severe depression, myasthenia gravis, severe organ dysfunction, and drug allergy. Have participated in clinical research of other drugs or medical devices in the past 3 months;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Qor-15 score at 24 h postoperatively; | — |
Secondary
| Measure | Time frame |
|---|---|
| Qor-15 score at 48 h postoperatively;Qor-15 score at 72 h postoperatively;Resting pain score at 2 h postoperatively;Resting pain score at 6 h postoperatively;Resting pain score at 12 h postoperatively;Resting pain score at 24 h postoperatively;Resting pain score at 48 h postoperatively;Pain score during activity at 12 h after surgery;Pain score during activity at 24 h after surgery;Pain score during activity at 48 h after surgery;Agitation-sedation (RASS) score after awakening in PACU;Agitation-sedation (RASS) score at 4 hours after surgery;Agitation-sedation (RASS) score at 12 hours after surgery;Agitation-sedation (RASS) score at 24 hours after surgery;Agitation-sedation (RASS) score at 48 hours after surgery;Intraoperative dosage of remifentanil;Intraoperative dosage of remimazolam;Intraoperative dosage of Ciprofol;The use of vasoactive drugs during surgery;Time required for extubation after surgery;The rate of salvage analgesia in PACU;The length of stay in PACU;The incidence of delirium and agitation in PACU;Fluid intake during surgery;Blood loss during surgery;Urine output during surgery;The occurrence of adverse reactions within 48 hours after surgery; | — |
Countries
China
Contacts
Public ContactYing Wang
The First Affiliated Hospital of Zhengzhou University
Outcome results
None listed