Primary aldosteronism
Conditions
Interventions
Gold Standard:adrenal vein sampling and PASO outcome
Index test:[18F] AldoView PET/CT
Sponsors
Xiangya Hospital of Central South University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1 . age > 18 years ; 2 . Understand the whole process of the experiment, volunteer to participate in the study and sign the informed consent ; 3 . The diagnosis of PA : screening positive, that is, standing plasma aldosterone / renin ratio, ARR >= 20 ( pg / ml ) / ( µIU / ml ) or ARR >= 30 ( ng / dL ) / ( ng / ml / hr ) and at least one diagnostic test was positive ( plasma aldosterone >= 110pg / ml after captopril inhibition test ( CCT ) or plasma aldosterone >= 100pg / ml after sitting saline load test ( SIT ) ) ; 4 . CT or MRI imaging examinations suggest that there are clear or suspicious lesions in the adrenal gland, which can be manifested as adrenal nodules or thickening of the adrenal gland.
Exclusion criteria
Exclusion criteria: 1 .Refuse to join the test, the patient or close relatives can not understand or sign the informed consent ; 2 . patients with other common secondary hypertension, such as renal artery stenosis, renal parenchymal hypertension, pheochromocytoma, hypercortisolism, etc; 3. Complicated with malignant tumor or severe heart, lung, kidney and liver dysfunction ; 4. pregnant or lactating women, women with pregnancy plans during the trial period, and women at high risk of pregnancy who have not taken any contraceptive measures ; 5. had undergone adrenal surgery ; 6 . Patients with adrenocortical dysfunction requiring hormone replacement therapy ; 7.Long-term use of glucocorticoids and can not be discontinued.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The sensitivity and specificity of classification diagnosis;Percentage of biochemical complete remission; | — |
Secondary
| Measure | Time frame |
|---|---|
| Proportion of clinical complete remission;Changes in Systolic blood pressure;The number of antihypertensive drugs reduced;The cure rate of hypertension;The accuracy of the prediction model for PA classification diagnosis;Predicting the accuracy of postoperative pathology; | — |
Countries
China
Contacts
Public ContactLuo Xianghang; Jiang Tiejian
Xiangya Hospital of Central South University
Outcome results
None listed