Positive response to tracheal intubation
Conditions
Interventions
Propofol group:The initial dose of propofol is 2mg/kg, administered over 30 seconds. If the previous patient exhibits a positive response, the dose is increased for the next patient. If the previous p
Ciprofol group:The initial dose of ciprofol is 0.4mg/kg, administered over 30 seconds. If the previous patient exhibits a positive response, the dose is increased for the next patient. If the previou
Sponsors
The First Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Voluntarily participate and sign the informed consent form. 2.Scheduled to undergo urological surgery under general anesthesia with tracheal intubation, with an ASA physical status classification of I-III. 3.Age >=60 years. 4.Body mass index (BMI) between 18 and 28 kg/m². 5.Diagnosed with sarcopenia.
Exclusion criteria
Exclusion criteria: 1.Contraindications to general anesthesia. 2.Allergy to the study drugs (ciprofol, propofol, sufentanil, or rocuronium). 3.Severe cardiovascular or cerebrovascular diseases, respiratory diseases, hematological disorders, endocrine disorders, or hepatic/renal dysfunction. 4.Predictable difficult airway or high-risk factors for difficult laryngoscopy/intubation. 5.Positive Allen’s test or hemodynamic instability (systolic blood pressure 180 mmHg, diastolic blood pressure >110 mmHg, heart rate =110 beats/min, or peripheral oxygen saturation <90%). 6.Inability to communicate effectively.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Tracheal intubation response;The ED50 of propofol or ciprofol for suppressing tracheal intubation response; | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart rate;Time to Loss of consciousness after administration of propofol or ciprofol;Injection pain;Adverse reactions;Bispectral index;Mean arterial pressure;Diastolic blood pressure;Systolic blood pressure; | — |
Countries
China
Contacts
Public ContactXuesheng Liu/Hu Liu/Chen Chen
The First Affiliated Hospital of Anhui Medical University
Outcome results
None listed