Skip to content

Structural-functional network alteration and prognostic outcome prediction of abnormal cognitive flexibility in adolescents with mild brain injury based on the prefrontal striatal pathway

Structural-functional network alteration and prognostic outcome prediction of abnormal cognitive flexibility in adolescents with mild brain injury based on the prefrontal striatal pathway - The Neural Mechanism of Cognitive Flexibility Deficit in Adolescents with Mild Traumatic Brain Injury

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500097247
Enrollment
Unknown
Registered
2025-02-14
Start date
2025-03-01
Completion date
Unknown
Last updated
2025-02-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mild Traumatic Brain Injury

Interventions

Adolescents with Mild Traumatic Brain Injury group:None
Healthy control group:None

Sponsors

School of Mental Health, Wenzhou Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
12 Years to 18 Years

Inclusion criteria

Inclusion criteria: Age range: Select 100 teenagers aged 12-18. In addition, it meets the diagnostic criteria for mild TBI developed by the Working Group of the Collaborating Centre for NeuroTrauma of the World Health Organization: i. The presence of one or more of the following symptoms: mental confusion or disorientation, loss of consciousness for 30 minutes or less, temporary seizures within a coma of less than 24 hours, local nerve damage, intracranial lesions that do not require surgery; ii. The Glasgow Coma score is 13-15. Inclusion criteria also included: no more than 72 hours from the time of the outpatient visit or admission to the hospital, and no audio-visual impairment or intellectual problems before the trauma.

Exclusion criteria

Exclusion criteria: Exclusion criteria included: the above symptoms of drug or alcohol-induced injury, a history of immediate brain trauma, a history of brain surgery, a history of mental or neurological problems, a history of mental illness in a first-degree relative, and use of psychotropic drugs within the last three months; A history of alcohol dependence or drug abuse; There are metal implants in the body, there are MRI scanning contraindications.

Design outcomes

Primary

MeasureTime frame
Multimodal neuroimaging index;

Secondary

MeasureTime frame
clinical neuropsychology test index;

Countries

China

Contacts

Public ContactHui Xu

Wenzhou Medical University

huixu@wmu.edu.cn+86 181 7959 9330

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026