hyperplastic scar
Conditions
Interventions
Retinoic acid group (Group A):Apply retinoic acid cream to the healed surgical incision twice a day for three months.
Silicone scar gel (Group B):Apply silicone scar gel to the healed surgical incision twice a day for three months.
Sponsors
the First Affiliated Hospital of Air Force Military Medical University
Eligibility
Sex/Gender
All
Age
12 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1) Patients aged 12-75 years after trauma and surgery; 2) Type-I incisions and type-II non-infectious Class A healing linear incisions on the trunk and extremities include: Neck thyroid surgery incision, breast cancer, breast reconstruction, giant mastectomy, breast prosthesis implantation (areolar incision, submammary fold incision), rib nose incision, donor skin and flap incision, abdominal wall molding wound, spine and limb post-operative wound, closed fracture of the trunk, benign and malignant tumors, spine and limb post-operative wound, closed fracture of the trunk, Benign and malignant tumors, thoracotomy incisions, abdominal non-infectious incisions, such as benign tumors, transplant surgery; 3) Subjects fully understand the research purpose and protocol of this study; 4) The subjects are willing to take the test and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1) Patients younger than 5 years and older than 75 years; 2) Patients at the end of their disease who may be lost to follow-up; 3) Subjects with clear scar constitution and pathological scar history; 4) Subjects diagnosed with scleroderma; 5) Class III incision; 6) The incision develops into a chronic wound; 7) There are benign and malignant diseases that affect the physiological state of the skin; 8) Have A clear history of allergy and adverse reactions to silicone and retinoic acid; 9) Pregnant and lactating women; 10) Incorporate other treatments that may affect the results, such as lasers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Whether there was hypertrophic scar 3 months after the operation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Whether hypertrophic scars occurred after 1 or 2 months of postoperative medication;The thickness of hypertrophic scar protruding from body surface thickness after 1, 2,3 months of postoperative medication;Vancouver Scale scores of hypertrophic scars 1, 2,3 months after treatment;POSAS scale score of hypertrophic scar 1, 2,3 months after treatment; | — |
Countries
China
Contacts
Public ContactBaoqiang Song
The First Affiliated Hospital of Air Force Military Medical University
Outcome results
None listed