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Exploration of repeated high-frequency transcranial magnetic stimulation for the treatment of acute phase aphasia in post-stroke patients

Exploration of repeated high-frequency transcranial magnetic stimulation for the treatment of acute phase aphasia in post-stroke patients

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500097224
Enrollment
Unknown
Registered
2025-02-14
Start date
2025-02-14
Completion date
Unknown
Last updated
2025-02-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ischemic Stroke?Post-stroke aphasia

Interventions

Test group:Targeting the left M1 region, sustained high-frequency stimulation at 80-100% TEP at 10Hz was effective for 5 minutes each time, twice a day for a total of 5 days.
Control group:Consistent with the protocol of the experimental group, the magnetic stimulation probe is a pseudo-stimulation probe, which only has sound but does not actually produce stimulation.

Sponsors

The First Affiliated Hospital of Chongqing Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1.Age>=18 years old; 2.Head MR confirms new onset of cerebral infarction, and aphasia symptoms are caused by cerebral infarction; 3.The patient's hospitalization period is within 7 days; 4.Can cooperate to complete all required inspection items and scales; 5.Sign informed consent form; 6.Right-handed hand.

Exclusion criteria

Exclusion criteria: 1.Patients with aphasia caused by non cerebral infarction,; 2.Non acute phase cerebral infarction patients with a course of more than 7 days; 3.Severe neurological disorders other than stroke, such as epilepsy and hemorrhagic stroke, are combined; 4.Patients with poor general condition and unable to complete relevant examinations and scale scores, such as patients with malignant arrhythmia, tumor, severe infection, malignant hypertension, diabetes hyperosmolar coma, etc; 5.Previous or current comorbidities of severe mental illnesses, such as depression, schizophrenia, etc; 6.Patients who have previously or currently taken sedatives or large amounts of sleep aids; 7.Contraindications for combined transcranial magnetic stimulation:; 8.Pregnancy and lactation period.

Design outcomes

Primary

MeasureTime frame
Boston Diagnostic Aphasia Examination, BDAE score;

Secondary

MeasureTime frame
Brain network metrics;Other scale scores(Scale for Modified Rankin Scale (MRs)National Institute of Health stroke scale (NHISS));

Countries

China

Contacts

Public ContactFei Xiao

The First Affiliated Hospital of Chongqing Medical University

feixiao81@126.com+86 23 89011876

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026