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Development of a Screening Model for Osteoporosis Based on Hematological Bone Metabolism Indicators and Evaluation of Its Application Effects

Development of a Screening Model for Osteoporosis Based on Hematological Bone Metabolism Indicators and Evaluation of Its Application Effects

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500097213
Enrollment
Unknown
Registered
2025-02-14
Start date
2025-03-01
Completion date
Unknown
Last updated
2025-02-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoporosis

Interventions

Observation group:None

Sponsors

Shanghai Sixth People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
45 Years to 90 Years

Inclusion criteria

Inclusion criteria: Inclusion Criteria: (1) Female, aged between 45 and 90 years, who underwent bone density DXA examination at our hospital with complete bone density data. (2) Completeness of blood test data at our hospital exceeds 80%. Blood indicators include: liver function(ALT,AST,ALP,GGT,TBil,DBil,TP,ALB), kidney function(CREA,UA),electrolytes (K, Na, Cl,Ca,P,Mg),lipid profile four items(TC,TG, HDL-C,LDL-C), thyroid function(FT3,FT4,TSH,PTH),calcium and phosphorus metabolism regulation markers (PTH,CT,25-(OH)2D3), bone metabolism markers(tP1NP,ß-CTx,NMID),and , among others.

Exclusion criteria

Exclusion criteria: (1) Severe abnormalities in liver function, kidney function. (2) Women with unknown menopausal status. (3) Long-term use (for more than 3 months) of medications that may affect bone metabolism (e.g., bisphosphonates, hormone replacement therapy, etc.). (4) Presence of severe medical conditions or malignant tumors that may influence bone metabolism. (5) History of major surgery or fractures within the recent 3 months.

Design outcomes

Primary

MeasureTime frame
ALT(Liver Function);AST(Liver Function);ALP(Liver Function);GGT(Liver Function);TBil(Liver Function);DBil(Liver Function);TP(Liver Function);ALB(Liver Function);CREA( Kidney Function);UA( Kidney Function);K(Electrolytes);Na(Electrolytes);Cl(Electrolytes);Ca(Electrolytes);P(Electrolytes);Mg(Electrolytes);TC(Lipid Profile Four Items);TG(Lipid Profile Four Items);HDL-C(Lipid Profile Four Items);LDL-C(Lipid Profile Four Items);FT3(Thyroid Function);FT4(Thyroid Function);TSH(Thyroid Function);PTH(Thyroid Function);PTH(Calcium and Phosphorus Metabolism);CT(Calcium and Phosphorus Metabolism);25-(OH)2D3(Calcium and Phosphorus Metabolism);tP1NP(Bone Metabolism);ß-CTx(Bone Metabolism);NMID(Bone Metabolism);T-score-guided diagnosis of osteoporosis (normal bone mass, osteopenia, osteoporosis);—

Countries

China

Contacts

Public ContactDu yuzhen

Shanghai Sixth People's Hospital

yzdu@sjtu.edu.cn+86 189 3017 3609

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026