Burns, Burn shock, organ dysfunction after burns
Conditions
Interventions
Methylene blue plus standard care group:Methylene blue is infused intravenously at a bolus of of 2 mg/kg, and then maintained at 0.25 mg/kg/h until 72h after burns
Standard care group:Fluid resuscitation was carried out according to the formula of the Third Military Medical University.
Sponsors
The First Affiliated Hospital of Army Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Provision of signed and dated informed consent form; 2.Flame burns and scald burns; 3.Aging 18-65 years; 4.Burn patients with 30% or greater of total body surface area (TBSA) burn and equal to or less than 80% TBSA burn; 5.Admitted earlier than 12h after burns; 6.Anticipated hospital stay: 7 days or more;
Exclusion criteria
Exclusion criteria: 1.Known allergic reactions to components of the methylene blue, phenothiazines, food dyes; 2.Pregnancy or lactation; 3.Deficiency of G6PD gene or family history; 4.Exposure to 5-HT inhibitors in the past 4 weeks; 5.Predicted death in 72h; 6.Severe inhalation injury; 7.Chronic kidney/ liver dysfunction, lung infection and other severe basic conditions; 8.Tumor;
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Organ dysfunction days;All-cause mortality;?mSOFA7;Incidence of POD;Coefficient of the fluid resuscitation during burn shock;Amount of vasoactive agents during burn shock;lactate clearance rate;Wound healing time per burn index;Inflammation and stress levels;Nitric oxide signaling levels;Quality of life;Incidence of adverse event; | — |
Primary
| Measure | Time frame |
|---|---|
| Incidence of new-onset / worsening organ dysfunction between randomization and 7 days after burns.; | — |
Countries
China
Contacts
Public ContactGaoxing Luo
The First Affiliated Hospital of Army Medical University
Outcome results
None listed