Lung mass
Conditions
Interventions
Intubation group:Midazolam 0.05mg/kg + sufentanil 0.3-0.5ug/kg + propofol 2mg/kg + cis atracurium 0.2-0.3mg/kg + esomeprazole 40mg were used to induce, and the double-lumen endotracheal tube was inser
LMA group:It was induced with midazolam 0.05 mg/kg + sufentanil 0.1-0.2 ug/kg + propofol 2 mg/kg + ketamine 0.2-0.3 mg/kg + esomeprazole 40 mg. After the patient loses consciousness, a double-lumen la
HFNC group:It was induced with midazolam 0.05 mg/kg + sufentanil 0.1-0.2 ug/kg + propofol 2 mg/kg + ketamine 0.2-0.3 mg/kg + esomeprazole 40 mg. After the patient loses consciousness, the nasopharynge
Sponsors
The First Affiliated Hospital of Guangzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) First thoracic surgery; (2) aged between 18 and 65 years, (3) BMI between 18-25kg/m^2; (4) ASA (American Society of Anesthesiologists physical status) Level I-II; (5) Patients with good cardiopulmonary function and no serious underlying diseases and severe pulmonary dysfunction.
Exclusion criteria
Exclusion criteria: 1) History of previous thoracic surgery; 2) pregnant or lactating females; 3) Severe cardiopulmonary impairment, hepatic or renal insufficiency; 4) Patients with high risk of reflux aspiration: gastroesophageal reflux disease, hiatal hernia, peptic ulcer, achalasia, congenital pyloric stenosis, acute abdomen, etc.; 5) Patients with abnormal nasal anatomy (nasal septum deviation, nasal bone fracture, etc.) and severe nasal obstruction 6) Those who cannot wear HFNC due to facial or upper respiratory tract surgery; 7) Central nervous system diseases, such as dementia, schizophrenia, etc.; 8) Combined with hyperthyroidism or hypothyroidism; 9) history of allergy to anesthetic drugs; 10) Difficult airway: Mallampati airway grade III or IV, temporomandibular joint ankylosis or difficulty opening the mouth (mouth opening degree < 2cm), mandibular deformity, ankylosing spondylitis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood gas analysis;Hemodynamic parameter changes(arterial blood pressure and heart rate);Evaluation of surgical effects;Postoperative recovery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Total anesthetic consumption;Pain numeric rating scores (NRS) at 24 and 48h;Perioperative laboratory results; | — |
Countries
China
Contacts
Public ContactLan Lan
The First Affiliated Hospital of Guangzhou Medical University
Outcome results
None listed