hereditary spastic paraplegia
Conditions
Interventions
intervention group:intermittent theta burst stimulation+conventional rehabilitation training
control group:sham stimulation+conventional rehabilitation training
Sponsors
The First Affiliated Hospital of Fujian Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) Age >= 18 years; (2) Patients with HSP who meet the diagnostic criteria for HARDING and are eligible for a genetically confirmed diagnosis; (3) Patients can walk with or without assistive devices; (4) No previous history of mental illness; (5) Able to cooperate with all assessments and examinations and voluntarily sign the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Severe illness or unconsciousness; (2) Contraindications to TMS such as metal implants or pacemakers in the head, presence of a history of seizures; (3) Women preparing for pregnancy, pregnant or breastfeeding; (4) Concurrent participation in other clinical studies; (5) Received magnetic stimulation therapy in the last six months; (6) Presence of other serious diseases, such as myocardial infarction, severe hepatic or renal dysfunction, severe infection or severe diabetes mellitus etc; (7) Inability to cooperate with all assessments and examinations or refusal to sign the informed consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| walking ability; | — |
Secondary
| Measure | Time frame |
|---|---|
| disease severity;muscle tone;muscle strength;balance ability;balance ability;walking ability;activity of daily living;walking ability;neural pathway; | — |
Countries
China
Contacts
Public ContactJun Ni
The First Affiliated Hospital of Fujian Medical University
Outcome results
None listed