Hemorrhoids
Conditions
Interventions
Experimental group:Starting 14 days before surgery, Lactobacillus paracasei is administered three times per day, once a sachet, dissolved in warm water (35-40°C) before consumption.
Control group:Starting 14 days before surgery, heat-inactivated Lactobacillus paracasei is administered three times a day, once a sachet, dissolved in warm water (35-40°C) before consumption.
Sponsors
Shenzhen People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) Patients aged 18-70 years with mixed hemorrhoids, scheduled to undergo mixed hemorrhoidectomy (Milligan-Morgan procedure) in the colorectal surgery department; (2) No mental disorders and capable of normal communication; (3) Willing to participate in the study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: (1) History of severe intestinal diseases (e.g., Crohn’s disease, ulcerative colitis); (2) Known immune deficiency; (3) Patients using antibiotics or immunosuppressants; (4) Patients with severe systemic diseases (e.g., severe cardiac, hepatic, or renal insufficiency); (5) Pregnant women, women within 6 months postpartum, or currently breastfeeding; (6) Patients with alcohol addiction; (7) Women of childbearing age planning to become pregnant during the study period; (8) Currently participating in another clinical study or having completed one within the past 60 days; (9) Unable to understand and comply with study requirements; (10) Patients requiring prolonged bed rest after surgery; (11) Other reasons deemed unsuitable for enrollment by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual Analogue Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Usage rate and intensity of analgesic medications;Incidence of urinary retention;Incidence of defecation difficulty;Postoperative quality of life score (SF-36);APS-POQ-R score; | — |
Countries
China
Contacts
Public ContactBiaohuan Zhou
Shenzhen People's Hospital
Outcome results
None listed