Hepatocellular carcinoma
Conditions
Interventions
Constipated group:Xylooligosaccharides (XOS-95 type) powder (3 g per sachet) for oral administration
Diarrheal group:Xylooligosaccharides (XOS-95 type) powder (1.5 g per sachet) for oral administration
Sponsors
Affiliation Hospital of JiangNan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for patients with constipation (1) Liver cancer patients whose clinical or pathological diagnosis met the criteria for Diagnosis and Treatment of primary liver Cancer (2024 edition); (2) Age >=18 years old; (3) Child-Pugh score =18 years old; (3) Child-Pugh score <=7, Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1; (4) BMI 18.5-28; (5) The patient had diarrhea during the perioperative period, which met the diagnostic criteria for diarrhea and had stool type 6-7 based on the Bristol stool Form Scale; (6) Did not receive the initial treatment and did not participate in other clinical research at least one week before entering the study; (7) Voluntarily participated in this study and signed the informed consent.
Exclusion criteria
Exclusion criteria: 1: The presence of other malignant tumors; 2: Expected survival time of less than 6 months; 3: Presence of severe complications such as serious cardiopulmonary dysfunction, coagulopathy, or decompensated liver cirrhosis; 4: Use of antibiotics and probiotic products (including long-term consumption of yogurt and probiotic drinks) within the past three months; 5: Poor compliance, unable to adhere to the clinical trial protocol for oral xylooligosaccharides.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Patient gastrointestinal function status score.;Fecal microbiota.;Blood sample (blood routine examination, liver function, tumor markers, and immune cell status); | — |
Secondary
| Measure | Time frame |
|---|---|
| Progression Free Survival;Overall survivial; | — |
Countries
China
Contacts
Public ContactWu Qinghua
Affiliation Hospital of JiangNan University
Outcome results
None listed