Attention deficit hyperactivity disorder, ADHD
Conditions
Interventions
Lactobacillus reuteri LR99 combined with behavioral intervention group (LR99 group):The probiotic preparation was taken once a day for 12 weeks. The oral probiotic was Limosilactobacillus reuteri LR99
Behavioral intervention group:Purely behavioral intervention group
Sponsors
Sichuan Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
6 Years to 12 Years
Inclusion criteria
Inclusion criteria: (1) Children aged 6-12 who are enrolled in primary school; (2) Meets DSM-5 diagnostic criteria for ADHD; (3) have not taken ADHD treatment drugs in the past; (4) Parents voluntarily participate and sign the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Age < 6 years or over 12 years old; (2) Use of various antifungal drugs, antibiotic drugs, immunosuppressive drugs, and antipsychotic drugs (package) in the past month including ADHD treatments) and other alternative therapies of probiotics, prebiotics, macronutrients and others; (3) Have AIDS, Crohn's disease, ulcerative colitis or cancer; (4) receiving chemotherapy; (5) Other unstable or serious heart, pulmonary, hepatic, kidney, hematopoietic system diseases (including unstable angina, uncontrollable asthma, severe allergies, active gastric bleeding, acute leukemia, etc.).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| SNAP-IV questionnaire;Results of cytokine detection and analysis of saliva and stool microbiota; | — |
Secondary
| Measure | Time frame |
|---|---|
| Conners questionnaire;Weiss Functional impairment Rating Scales;Follow-up was terminated for various reasons through the start of the study through 12 weeks; | — |
Countries
China
Contacts
Public ContactLi Jie
Sichuan Provincial People's Hospital
Outcome results
None listed