Postoperative nausea and vomiting
Conditions
Interventions
Glonbromide group:The patients will be intravenously given 5 µg / kg of Gronbromide 10 min before the start of the examination.
Penehyclidine hydrochloride group:Patients will be intravenously given penehyclidine hydrochloride 0.01 mg / kg 10 min before the start of the examination.
Sponsors
Henan Provincial Chest Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: ( 1 ) Age : 18 years <= age < 64 years ; ( 2 ) Body mass index ( BMI ) : 18 kg / m2 <= BMI < 30 kg / m2 ; ( 3 ) American Society of Anesthesiologists ( ASA ) classification : I ~ III ; ( 4 ) Type of surgery : elective painless gastrointestinal endoscopy.
Exclusion criteria
Exclusion criteria: ( 1 ) Glaucoma; ( 2 ) Allergic to glononium bromide, penehyclidine, atropine, scopolamine or other anticholinergic drugs; ( 3 ) acute or chronic nausea or vomiting, or preoperative gastrointestinal motility disorders; ( 4 ) history of schizophrenia, Parkinson 's disease, severe dementia or language disorder; ( 5 ) severe liver dysfunction ( Child-Pugh C ), severe renal dysfunction; ( 6 ) Difficult airways are expected; ( 7 ) Patients involved in other clinical studies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of PONV; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence and severity of PON and POV;The severity of pain;Patient satisfaction with PONV management;The number of cases of postoperative remedial antiemetic drugs;The average time of first anal exhaust after operation;Incidence of postoperative adverse reactions; | — |
Countries
China
Contacts
Public ContactYingchun Guo
Henan Provincial Chest Hospital
Outcome results
None listed