None
Conditions
Interventions
Ciprofol group:During the induction of anesthesia, 0.3 mg/kg of ciprofol was infused intravenously over 30 seconds. During the maintenance of anesthesia, the rate of ciprofol infusion was adjusted acc
Propofol group:During the induction of anesthesia, 1.5 mg/kg of propofol was infused intravenously over 30 seconds, and during the maintenance of anesthesia, the rate of propofol infusion was adjusted
Sponsors
The First Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age >= 65 years; 2. Meets the FRAIL Frailty Scale criteria for frailty; 3. Elective surgery that is not cardiothoracic or non-traumatic brain surgery; 4. the patient can communicate normally, and the patient or designee has signed an informed consent form.
Exclusion criteria
Exclusion criteria: 1. allergy to any of the drugs administered in the study; 2. Body mass index (BMI) >=30 kg/m^2; 3. History of severe hepatic injury, that is, Child-Pugh class C; 4. Currently on maintenance dialysis; 5. Congestive heart failure, such as New York Heart Association cardiac class III or IV; 6. untreated or unstable ischemic heart disease; 7. history of severe aortic or mitral valve disease; 8. use of antidepressants or antipsychotics; 9. anticipated difficulties with airway management; 10. Unsuccessful initial intubation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of hypotension after anesthesia induction; | — |
Secondary
| Measure | Time frame |
|---|---|
| Use of vasoactive drugs;Pain of injection;lost the consciousness time;Incidence of postoperative nausea and vomiting;Quality of postoperative recovery; | — |
Countries
China
Contacts
Public ContactQiying Shen
the First Affiliated Hospital of Anhui Medical University
Outcome results
None listed