Perioperative intracranial pressure
Conditions
Interventions
Lidocaine low-dose group (L1 group):Lidocaine 1mg/ (kg·h)
Lidocaine high-dose group (L2 group):Lidocaine 2mg/ (kg·h)
Sponsors
Ningxia Hui Autonomous Region People's Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1) Gynecological laparoscopic surgery with low head and high foot, including laparoscopic adjunct resection, laparoscopic myomectomy and laparoscopic total hysterectomy; 2) Age 18-60 years old; 3) A body mass index (BMI) of 18-25 kg/m2; 4) American Society of Anesthesiologists ASA grade I ~ II; 5) Have normal cognitive and communication skills.
Exclusion criteria
Exclusion criteria: 1) History of drug allergy to lidocaine; 2) The operation time is less than 1h or more than 3h; 3) Previous history of laparoscopic surgery, ophthalmic surgery or neurosurgery; 4) Combined with a history of eye diseases, such as ocular trauma, optic neuritis, optic nerve tumor, glaucoma, etc. 5) Combined with central nervous system diseases and cerebrovascular diseases, such as motion sickness, craniocerebral trauma, intracranial infection, cerebral infarction, cerebral hemorrhage, brain tumor, etc.; 6) Combined with severe respiratory, circulatory or endocrine system diseases; 7) Recently take drugs that affect cerebrospinal fluid pressure, such as diuretics, glucocorticoids, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Optic nerve sheath diameter; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intraoperative vital signs;Recovery time for spontaneous breathing;Awakening time;Extubation time;Recovery room residence time;Riker rating;Postoperative VAS pain score;Three day postoperative complications;Occurrence and extent of adverse reactions related to lidocaine (perioral numbness, bradycardia, hypotension);Use of emergency antiemetic drugs;Use of emergency analgesics; | — |
Countries
China
Contacts
Public ContactZhenhai Ye
Ningxia Hui Autonomous Region People's Hospital
Outcome results
None listed