Patients with a history of using anti bone resorption drugs and/or anti angiogenic drugs, and whose bodies can tolerate tooth extraction surgery
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. History of using anti bone resorption drugs and/or anti angiogenic drugs; 2. The body can tolerate tooth extraction surgery; 3. Chronic inflammation in the mouth (such as chronic periodontitis or periapical periodontitis) or teeth without preservation significance; 4. After evaluation, the use of anti bone resorption or anti angiogenesis drugs can be suspended for at least 6 weeks during the drug suspension window period; 5. Age over 18 years old;
Exclusion criteria
Exclusion criteria: 1. History of Head and Neck Radiotherapy; 2. Individuals with a history of primary or metastatic malignant tumors in the oral or jawbone; 3. Individuals whose overall condition cannot tolerate surgery; 4. Children (under 18 years old) or pregnant patients;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Early Wound-Healing Index(EHI); | — |
Secondary
| Measure | Time frame |
|---|---|
| Subjective indicator pain evaluation: Visual Analog Rating Scale;Is there redness and swelling of the oral mucosa, and bone exposure;Complications: safety indicators such as maxillary sinus perforation and inferior alveolar nerve injury; | — |
Countries
China
Contacts
China-Japan Friendship Hospital