Pregnant or postpartum women aged =18 years
Conditions
Interventions
Gold Standard:The 2016 European Society of Intensive Care Medicine and the American Society of Intensive Care Medicine published the sepsis 3.0 diagnostic criteria, which is a sequential organ failure
Index test:Blood gas analysis, complete blood count, total bilirubin, blood pressure, GCS score, blood creatinine
Sponsors
The Third Affiliated Hospital of Guangzhou Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Inclusion criteria for the sepsis group: ? Pregnant women or women in the puerperium, aged = 18 years; 1.? Meet the diagnostic criteria for sepsis 3.0 published by the European Society of Intensive Care Medicine and the American Society of Intensive Care Medicine in 2016, that is, a sequential organ failure assessment (SOFA) score = 2 in the presence of a clear focus of infection. 2. Inclusion criteria for the non-sepsis group: ? pregnant women or women in the puerperium, ? those who do not meet the 2016 European Society of Intensive Care Medicine and the American Society of Intensive Care Medicine's sepsis 3.0 diagnostic criteria (see above for diagnostic criteria);
Exclusion criteria
Exclusion criteria: 1.? Age < 18 years; 2.? Patients with a history of confirmed hematopoietic stem cell transplantation; 3.? Patients with a history of confirmed rheumatic immune system diseases who are still being treated; 4.? Patients who have given up treatment after entering the ICU.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Infection markers (CRP, PCT, IL-6, SAA);;anti-inflammatory factors (TNF- a, IFN- ?, IL-1 a, IL-1 ß, IL-6, IL-8, IL-10, IL-4, IL-1Ra);cytokines (TGF-ß );(Lymphocyte classification) Neutrophils, monocytes, DC cells, NK cells;PD-1;Accuracy;Sensitivity;Specificity; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pathogen detection using polymerase chain reaction technology;Pathogen spectrum detection by mNGS;Immunoprofiling; | — |
Countries
China
Contacts
Public ContactJialin Yang
The Third Affiliated Hospital of Guangzhou Medical University
Outcome results
None listed