Chronic post-surgical pain
Conditions
Interventions
Bupivacaine liposome group:Ultrasound-guided thoracic paravertebral nerve block will be performed before the operation. Diluted bupivacaine liposome 15 ml ( 133 mg ) was given at T3-4 and T5-6.
Ropivacaine group:Ultrasound-guided thoracic paravertebral nerve block will be performed before the beginning of the operation. 0.33 % ropivacaine 15 ml ( 50 mg ) was given at T3-4 and T5-6 levels.
Sponsors
Henan Provincial Chest Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: Aged 18-64 years old ; preoperative or intraoperative pathological diagnosis of lung cancer requires thoracoscopic surgery ( lung wedge, lung segment, lung lobe ) ; american Society of Anesthesiologists ( ASA ) grade I-III ; patients or their legal representatives signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Communication disorders, inability to cooperate with the investigator, such as language comprehension disorders, psychiatric disorders, epilepsy, history of Parkinson's disease or myasthenia gravis, etc. 2. Identifying/suspected to have a history of alcohol, analgesic drugs, or other substance abuse and addiction. 3. Those who are allergic to the drugs in this study. 4. Long-term chronic pain before surgery. 5. Previous history of thoracic surgery. 6. Refusal to participate in this study. 7. In the opinion of the doctor in charge or the investigator, there are other conditions that are not suitable for participating in this study (the reasons need to be recorded). 8. Patients participating in other clinical studies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative chronic pain;The oxygenation index ( PaO 2 / FiO 2 ) was measured on the 1st and 3rd day after operation.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Acute Pain Intensity Post-Surgery;Total Consumption of Opioids within 48 Hours after Surgery;Frequency and dose of non-steroidal anti-inflammatory drugs ( NSAIDs ).;The first ambulation time after operation;Postoperative Complication Rate;Patients' satisfaction;Hospitalization time;Serum markers;The incidence of chronic pain at 3 months after operation.;The incidence of chronic pain at 12 months after operation.; | — |
Countries
China
Contacts
Public ContactJunhui Zhou
Henan Provincial Chest Hospital
Outcome results
None listed