periodontitis
Conditions
Interventions
healthy group:None
Sponsors
The First Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
All
Age
66 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Age>65 years old; 2. ASA grades I-IV; 3. Patients who plan to undergo large-scale non cardiac or non cranial surgery (surgery time>2 hours) under general anesthesia; 4. Agree to participate in this study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients who experienced delirium preoperatively (assessed using the 3D-CAM scale); 2. Patients who are unable to cooperate with the researchers for any reason, such as hearing or visual impairments, or language comprehension disorders; 3. Patients with a history of severe mental illness: such as cognitive impairment (assessed using the MMSE scale), depression, severe central nervous system depression, Parkinson's disease, basal ganglia lesions, schizophrenia, epilepsy, Alzheimer's disease, myasthenia gravis, etc., and those taking psychotropic medications; 4. Patients who have been on long-term corticosteroid therapy (including oral, intramuscular, or intravenous administration), or those taking probiotics or other microbial preparations; 5. Patients who lack the capacity to provide informed consent; 6. Patients who have received general anesthesia within 30 days preoperatively; 7. Patients who have undergone periodontal treatment within six months preoperatively; 8. Patients with more than 15 natural teeth, and at least 3 teeth in each quadrant; 9. Patients who have used antibiotics within six months preoperatively.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence and severity of postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative pain score;Postoperative hospitalization days;Postoperative pneumonia incidence rate;Postoperative ICU admission rate; | — |
Countries
China
Contacts
Public ContactLiu Xuesheng
The First Affiliated Hospital of Anhui Medical University
Outcome results
None listed