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Clinical application value of CD4/CD8 in evaluating the efficacy of different treatment methods for LSIL caused by HR-HPV infection

Clinical application value of CD4/CD8 in evaluating the efficacy of different treatment methods for LSIL caused by HR-HPV infection

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500097015
Enrollment
Unknown
Registered
2025-02-11
Start date
2023-09-18
Completion date
Unknown
Last updated
2025-02-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Low-grade squamous intraepithelial lesion of the cervix

Interventions

Retrospective analysis(focused ultrasound treatment group):Focused ultrasound therapy
Retrospective analysis (Leep treatment group):Leep treatment group
Retrospective analysis(Interferon treatment group):Drug therapy
Prospective cohort study(focused ultrasound treatment group):Focused ultrasound therapy
Prospective cohort study (Leep treatment group):Leep treatment group
Prospective cohort study(Interferon treatment group):Drug therapy

Sponsors

Chongqing University Affiliated Three Gorges Hospital
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1) not receiving other drugs, physical therapy, or major surgery within 3 months; 2) diagnosis of high-risk HPV infection by HPV-DNA testing; 3) LSIL was diagnosed if the colposcopy results were satisfactory (satisfactory: the cervical squamo-column junction was completely visible); 4) understand the condition and can express normally; 5) those who agreed to enter the cohort study and signed the consent form; 6) non-pregnant or lactating women; 7) no acute genital tract inflammation.

Exclusion criteria

Exclusion criteria: 1) patients who refuse to participate in the study; 2) co-infection with other sexually transmitted diseases; 3) other serious tissue, organ or system lesions; 4) unsatisfactory colposcopy or lesion located in the cervical canal; 5) uncontrolled diabetes, hyperthyroidism or hypothyroidism; 6) severe blood diseases, coagulation disorders, cardiovascular and cerebrovascular diseases, immune system diseases, etc.

Design outcomes

Primary

MeasureTime frame
Whether HPV turns negative;Cervical cytological examination;

Secondary

MeasureTime frame
Cluster of differentiation 4;Cluster of differentiation 8;Colposcopy;

Countries

China

Contacts

Public ContactMingju Huang

Chongqing University Affiliated Three Gorges Hospital

182290936@qq.com+86 189 9669 8122

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026