Intracranial hypotension Syndrome
Conditions
Interventions
Gold Standard:CT myelography
Index test:Spinal Magnetic Resonance Hydrography
Sponsors
Zhongshan Hospital Affiliated with Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1 Age is between 18 and 80 years old (inclusive), with no gender restriction. 2 All patients meet the diagnostic criteria for spontaneous intracranial hypotension proposed in the latest International Classification of Headache Disorders, 3rd edition (ICHD - 3) released by the International Headache Society in 2018: There is intracranial hypotension, that is, cerebrospinal fluid pressure < 60 mmH2O and/or imaging evidence of cerebrospinal fluid leakage; the occurrence of headache is closely related in time to intracranial hypotension or cerebrospinal fluid leakage, or the latter is diagnosed due to headache; there is a lack of processes or trauma that can lead to cerebrospinal fluid leakage; it cannot be better explained by other diagnoses in ICHD - 3. 3 The subject or their guardian can understand the purpose of the trial, is willing to cooperate with treatment and follow - up, voluntarily participates in the trial and signs the informed consent form.
Exclusion criteria
Exclusion criteria: Patients with secondary cerebrospinal fluid leakage caused by lumbar puncture, epidural anesthesia, craniocerebral or spinal cord trauma, etc. Pregnant women. Patients with implants such as intracranial aneurysm clips or cardiac implantable electronic devices in the body, who cannot undergo MRI. Patients with hemorrhagic diseases or bleeding tendencies and abnormal blood coagulation function. Patients with infectious lesions or open injuries at the puncture site. Patients allergic to iodine contrast agents. Patients with the spinal cord in a critical state. Patients with various malignant tumors, cachexia caused by chronic wasting diseases, severe shock that cannot be corrected by drugs, vital organ failure, or other serious diseases who cannot tolerate myelography. Subjects who are participating in other clinical trials and have not reached the time limit of the primary endpoint. Patients with other factors that, as judged by clinicians, are not suitable for this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Spinal Magnetic Resonance Hydrography;CT myelography;Accuracy;Sensitivity;Specificity; | — |
Countries
China
Contacts
Public ContactZHANG YUWEN
Zhongshan Hospital Affiliated with Fudan University
Outcome results
None listed