postoperative delirium
Conditions
Interventions
Ciprofol group :Cyclopofol (0.4 mg/kg/h) was used to maintain anesthesia, and 0.05 to 5 µg·kg-1·min-1 of remifentanil was continuously injected intravenously during the operation, and combined with s
Propofol group:Propofol (2 mg/kg/h) was used to maintain anesthesia, and 0.05 to 5 µg·kg-1·min-1 of remifentanil was continuously injected intravenously during the operation, and combined with sevoflu
Sponsors
Affiliated Hospital of Guizhou Medical University
Eligibility
Sex/Gender
All
Age
65 Years to 85 Years
Inclusion criteria
Inclusion criteria: (1) Age >= 65 years old (2) American Society of Anesthesiologists (ASA) Level I-III; (3) Orthopedic surgery under general anesthesia (4) Able to complete cognitive function tests independently (5) Voluntarily participate and sign informed consent.
Exclusion criteria
Exclusion criteria: (1) Those who have cognitive dysfunction as determined by the preoperative Mini-Mental State Examination (MMSE) (2) History of neurosurgery or cardiac surgery (3) Use of sedatives or antidepressants within 2 months before surgery (4) Severe hearing and vision loss (5) Severe liver dysfunction (Child-Pugh C stage) or renal insufficiency (requiring renal replacement therapy) (6) Parkinson's disease, Alzheimer's disease or coma (7) )Alcohol poisoning or drug dependence (8)Others deemed unsuitable for inclusion in the study after evaluation by the researcher.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| Respiratory and hemodynamic indices (mean arterial pressure (MAP) and heart rate (HR));Extraction time;Postoperative pain score;Length of hospitalization;Incidence of adverse reactions (e.g., IV pain, intraoperative knowledge, sore throat hoarseness, burning sensation in the throat, nausea and vomiting); | — |
Countries
China
Contacts
Public ContactTao Song
Affiliated Hospital of Guizhou Medical University
Outcome results
None listed