Parkinson's disease
Conditions
Interventions
Control group:None
Sponsors
Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine
Eligibility
Sex/Gender
All
Age
40 Years to 65 Years
Inclusion criteria
Inclusion criteria: Enrollment Criteria for PD Group: 1. A definite diagnosis of PD, 40y<=age<=65y; 2. PD is classified as TD-PD or PIGD-PD; 3. PD stage is H&Y grade <=2.5; 4. Medication: no oral trihexyphenidyl in the past 1 week; 5. Tremor in subjects with TD-PD manifested as limb tremor; Subjects with PIGD-PD present with bradykinesia of the upper limbs; 6. No contraindications to trihexyphenidyl use: cognitive or behavioral abnormalities (MoCA<26), voiding disorders, prostatic hypertrophy, angle-closure glaucoma. Enrollment criteria for normal control group: Gender, age matching, signed informed consent, and agreed to participate in clinical data collection and neuroelectrophysiological measurements.
Exclusion criteria
Exclusion criteria: Exclusion Criteria for PD Group: 1. TMS/electrophysiological contraindications: there is a metal object near the head; Presence of a history of epilepsy or a family history of epilepsy; Severe cardiovascular disease; History of non-reversible brain surgery; 2. Have a clear history of stroke, moderate to severe brain trauma, hydrocephalus, brain surgery or brain tumor in the past; 3. Severe psychiatric symptoms; 4. Unable to cooperate with the completion of the test. Exclusion Criteria for Normal Control Group: 1. History of neurodegenerative disease or related symptoms and signs; 2. Have a clear history of stroke, moderate to severe brain trauma, hydrocephalus, brain surgery or brain tumor in the past; 3. Severe cognitive impairment or psychiatric symptoms; 4. Unable to cooperate with the completion of the test
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Short latency afferent inhibition; | — |
Secondary
| Measure | Time frame |
|---|---|
| Resting motion threshold;Incoming-outgoing curves;Resting period;Interhemispheric inhibition;Brain activation; | — |
Countries
China
Contacts
Public ContactZhenguo Liu
Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine
Outcome results
None listed