Orthopedic related diseases
Conditions
Interventions
"Tranexamic acid combined with chewing gum" group:Chew gum for 20-30 minutes at 8:00, 12:00 and 18:00 every day before surgery and the first three days after surgery, respectively
Tranexamic acid was injected intravenously at 5h, 10h and 15h, respectively
The "chewing gum" group:Chew gum for 20-30 minutes at 8:00, 12:00 and 18:00 every day before surgery and the first three days after surgery respectively
Tranexamic acid group:Tranexamic acid was injected intravenously at 5h, 10h and 15h, respectively
Control group:Normal saline was injected intravenously at 5h, 10h and 15h after operation
Sponsors
Chongqing Orthopedic Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) Patients admitted to our hospital were diagnosed with lumbar degenerative diseases (lumbar disc herniation, lumbar spinal stenosis, lumbar spondylolisthesis); 2) Volunteer to participate in the study and sign the informed consent; 3) Hemoglobin (Hb) and coagulation function were normal before operation; 4) Color ultrasound of both lower limbs showed no abnormality.
Exclusion criteria
Exclusion criteria: 1) All patients with no such diagnosis were excluded from the study; 2) Preoperative anemia (Hb: female 1.4, or activated partial thrombin time (APTT) >1.4 times the normal value; 7) Serious heart, lung, liver, renal insufficiency.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gastrointestinal function indicators (first defecation, exhaust, bowel sound recovery time, constipation, abdominal distension, nausea, vomiting,oral comfort, etc.);Liver and kidney function (prealbumin, total protein, Alb, ALT, AST, BUN, Cr ,etc.);Inflammatory response related indicators;Drainage tube removal time, postoperative bed rest time to ambulation time, etc.;Postoperative complication(exudation, hematoma, infection, etc.);Postoperative wound drainage volume, HCT of postoperative wound drainage fluid;Pain-related parameter indicators;Blood loss related parameters (total blood loss,postoperative blood loss, dominant blood loss, hidden blood loss, intraoperative blood loss, drainage fluid blood content, etc.);Bood routine(HCTHbRBC;PLT);The incidence of thrombosis ( deep vein thrombosis, muscular calf vein thrombosis, pulmonary embolism, myocardial infarction, etc.); | — |
Secondary
| Measure | Time frame |
|---|---|
| Basic demographic parameters ( age, gender, height, weight, etc.);Length of stay ( total length of stay, preoperative length of stay, postoperative length of stay, etc.);Medical expenses;Duration of operation (min), length of incision (cm);Anesthesia related parameters ( ASA classification, cardiopulmonary function classification, Mallampati classification, etc.);Clinical diagnosis, past history, osteoporosis, etc.;Chalybeate, EPO, anti-inflammatory and analgesic drugs and other drugs use and follow-up.;Coagulation and fibrinolysis indexes(PTINRAPTTTTFIBFDPD-D);Coagulation factors(????????);Thrombelastogram(TEG); | — |
Countries
China
Contacts
Public ContactWei Dong
Chongqing Orthopedic Hospital of Traditional Chinese Medicine
Outcome results
None listed