CRE infection
Conditions
Interventions
Observation group:None
Sponsors
SUN YAT-SEN MEMORIAL HOSPITAL
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Age >18 years and <= 80 years; 2.Requires treatment with a combination of eravacycline and aminoglycosides for CRE infection, with a minimum treatment duration of =48 hours; 3.Agrees to participate in the clinical trial, is willing to undergo follow-up, and has signed a written informed consent form;
Exclusion criteria
Exclusion criteria: 1.Patients with a known history of allergy or severe adverse reactions to eravacycline or aminoglycoside antibiotics; 2.Patients with severe mental or neurological disorders prior to enrollment, rendering them unable to understand or comply with the requirements of the clinical trial; 3.Patients in the terminal stage of a disease (e.g., end-stage liver disease, end-stage renal disease) who are unlikely to benefit from treatment and have a limited life expectancy;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Synergistic effect of drug; | — |
Secondary
| Measure | Time frame |
|---|---|
| Synergistic mechanism;Mortality;level of inflammatory factors;Bacterial clearance efficiency; | — |
Countries
China
Contacts
Public ContactTang Xikang
Sun Yat-sen Memorial Hospital of Sun Yat-sen University
Outcome results
None listed