nsertion Response in Upper Gastrointestinal Endoscopy
Conditions
Interventions
Oliceridine group:20ug/kg Oliceridine + Propofol
Fentanil group:1ug/kg fentanil+propofol
Sponsors
Changshu NO.2 people's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients undergoing elective surgery under general anesthesia; 2. Aged 18-65 years; 3. American Society of Anesthesiologists (ASA) classification I-II; 4. Body mass index (BMI): 18-30 kg/m².
Exclusion criteria
Exclusion criteria: 1. Patients with insufficient fasting time (fasting <6h, drinking <2h) or gastrointestinal obstruction with gastric content retention; 2. Patients with mental disorders, intellectual disabilities, or hearing impairments; 3. Patients with a history of long-term use of sedative and analgesic drugs, drug abuse, or alcoholism; 4. Patients with severe heart, lung, kidney, liver, or other organ dysfunction; 5. Patients with pathological obesity, myasthenia gravis, severe depression, epilepsy, or a history of psychiatric disorders; 6. Patients with uncontrolled hypertension, glaucoma, hyperthyroidism, or pheochromocytoma; 7. Patients with a history of esophageal or gastrointestinal surgery, or gastrointestinal obstruction with gastric content retention.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 90% Effective Dose for Inhibiting the Insertion Response in Upper Gastrointestinal Endoscopy; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of adverse reactions such as pain on propofol injection, sinus bradycardia, hypotension, and body movement;Anesthesia induction time, gastrointestinal endoscopy duration, time to first body movement response or additional propofol administration, frequency and dosage of additional propofol; recovery time, defined as the time from anesthesia induction (OAAS score = 1) to the time the patient opens their eyes after the procedure;occurrence of adverse reactions during the recovery phase, including nausea, vomiting, agitation, and delirium;blood pressure, heart rate, and SpO2 at different time points: immediately after entering the endoscopy room (T1), immediately after OAAS score = 1 (T2), immediately after the endoscope enters the esophagus (T3), 2 minutes after the endoscope enters the esophagus (T4), and 1 minute after the patient wakes up (T5); | — |
Countries
China
Contacts
Public ContactWang Qian
Changshu NO.2 people's Hospital
Outcome results
None listed