Temporomandibular Disorders(TMDs)
Conditions
Interventions
Targeted-Closed-Loop Stimulation Experimental Group (Exposure Group):Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) Therapy
Control Group (Non-exposed Group):Transcutaneous Auricular Vagus Nerve Stimulation Sham Treatment
Sponsors
The Third Affiliated Hospital of Guangzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.In accordance with the diagnostic criteria for TMDs research; 2.Pittsburgh Sleep Quality Index (PSQI) score > 7; 3.No history of neurological or psychiatric related diseases; 4.No significant cognitive impairments, capable of cooperating to complete the corresponding rehabilitation training; 5.Male or female, aged between 18 to 80 years; 6.Patients who have not received various neuromodulation rehabilitation treatments; 7.No contraindications for taVNS and neuromuscular electrical stimulation; 8.Volunteers who are willing to participate in the study and have signed an informed consent form;
Exclusion criteria
Exclusion criteria: 1. Suffering from other mental health diseases (dementia, Parkinson's disease, depression, anxiety, schizophrenia, bipolar disorder, etc.); 2. Have uncontrolled epilepsy, that is, have had seizures within 4 weeks before enrollment; 3. Cardiac arrhythmia or other abnormalities; 4. History of respiratory illness or disorder, including dyspnea and asthma; 5. History of vasovagal syncope; 6. Receiving other neurostimulation/modulation therapy; 7. Difficulty in communication and understanding, unable to cooperate with the completion of the test; 8. Women who are pregnant or breastfeeding;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fonseca Anamnestic Index;variability in mouth opening degree;Changes in electrocardiographic characteristics (heart rate, heart rate variability)and respiratory characteristics;Visual Analogue Scale (VAS) pain scores; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pittsburgh Sleep Quality Index (PSQI) assessment scores; | — |
Countries
China
Contacts
Public ContactZhen Liu
The Third Affiliated Hospital of Guangzhou Medical University
Outcome results
None listed