Postspinal Anesthesia Hypotension
Conditions
Interventions
Low-dose group:A 0.05 ug/kg of initial prophylactic norepinephrine boluse after spinal anesthesia
High-dose group:A 0.1 ug/kg of initial prophylactic norepinephrine boluse after spinal anesthesia
Sponsors
General Hospital of Ningxia Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. Singleton full-term pregnancies aged 18-40 years old (including primiparous and multiparous women) undergoing cesarean section under combined spinal-epidural anesthesia; 2. ASA Grading I-II
Exclusion criteria
Exclusion criteria: 1. Height 100kg or BMI>=40kg/m2; 3. Eclampsia or chronic hypertension or basal systolic blood pressure >=160mmHg; 4. Hemoglobin<7g/dl; 5. Fetal distress or known abnormal fetal development
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ED50 and ED90 of prophylactic norepinephrine infusion; | — |
Secondary
| Measure | Time frame |
|---|---|
| Apgar scores;Incidence of adverse events;Umbilical artery blood gas;Number of norepinephrine interventions;General information (age; Height; Weight; BMI);Basic vital signs (systolic blood pressure, heart rate);Anesthesia plane;Anesthesia until delivery of the fetus;The time from incision to delivery of the fetus;Days of postoperative hospital stay;Total fluid volume; | — |
Countries
China
Contacts
Public ContactYi Chen
General Hospital of Ningxia Medical University
Outcome results
None listed