colorectal cancer
Conditions
Interventions
Oxycodone group:Oxycodone group (Q group): intravenous midazolam 0.03 mg/kg, oxycodone 0.3 mg/kg, propofol 1.5 mg/kg and cisatracurium 0.2 mg/kg were induced by anesthesia. Flurbiprofen cilofen 50 mg
Fentanyl group:Fentanyl group (group C): intravenous midazolam 0.03 mg/kg, fentanyl 2 µg/kg, propofol 1.5 mg/kg and cis-atracurium 0.2 mg/kg were induced, and flurbiprofen axil 50 mg and fentanyl inje
Sponsors
Tianjin People's Hospital
Eligibility
Sex/Gender
All
Age
20 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Inpatients who choose ASA grade I.~III. in our hospital and plan to undergo elective laparoscopic surgery; The operation time >= 3 hours; (2) Age >= 18 years old, gender is not limited; (3) The academic requirements need to be at the junior high school level or above (the duration of education > 6 years), and be able to understand the content of the NRS rating scale within an interpretable range.
Exclusion criteria
Exclusion criteria: (1) Gastrointestinal ischemic diseases (esophageal cancer, Crohn's disease, ulcerative intestinal diseases, necrotizing enteritis and stress ulcers, etc.); (2) Patients who continue to use psychotropic drugs; (3) Patients with severe heart, lung, liver, and kidney diseases; (4) Patients with hypertension and poor control, tachycardia and poor control; (5) Patients with severe visual and hearing impairments; (6) Patients who are unable or unwilling to cooperate in completing neurological dysfunction testing; (7) Patients with contraindications to the use of oxycodone.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| NRS pain scores at 2, 4, 8, 24, 48, 72 hours postoperatively;Use of salvage analgesics within 72 hours after surgery;Time to first postoperative gas and bowel movement;Postoperative gastrointestinal function;Serum I-FABP concentration;Gastrin (GAS) levels; | — |
Secondary
| Measure | Time frame |
|---|---|
| General preoperative;Intraoperative propofol dosage;Remifentanil dosage; | — |
Countries
China
Contacts
Public ContactShuhua Xie
Tianjin People's Hospital
Outcome results
None listed