Acute postoperative pain
Conditions
Interventions
Group A: Ulinastatin 10 IU administered perioperatively.
Group B: Ulinastatin 20 IU administered perioperatively.
Group C (control group):Administer Flurbiprofen ester 100 mg perioperatively.
Sponsors
The First Hospital of Shanxi Medical University.
Eligibility
Sex/Gender
All
Age
40 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1) Patients aged 40 to 85 years requiring knee/hip arthroplasty. 2) Conscious and capable of understanding the VAS (Visual Analog Scale) scoring. 3) ASA classification of I-III. 4) Patients who have signed the written informed consent for the study.
Exclusion criteria
Exclusion criteria: 1) Patients with neuropathic pain currently using or deemed by their physician to require anticonvulsant or antidepressant medications (e.g., due to tumor compression of nerve trunks, plexuses, or spinal cord); patients currently using or deemed by their physician to require analgesics other than the study medication. 2) Patients with unstable comorbid conditions, such as gastrointestinal ulcers, or those with significant organ dysfunction; patients with pain resulting from complex injuries. 3) Patients with severe psychiatric disorders or cognitive impairment who are unable to cooperate with the investigator in postoperative pain assessment. 4) Patients with known allergies to the investigational drug or contraindications for its use. 5) Patients who may alter their concomitant medications (excluding treatments for opioid adverse effects) during the study period. 6) Patients deemed by the investigator to be unsuitable for participation in this study for any reason beyond the inclusion and exclusion criteria.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Morphine consumption;Adverse reactions occurred; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain score; | — |
Countries
China
Contacts
Public ContactMeng Yujie
The First Hospital of Shanxi Medical University.
Outcome results
None listed