laparoscopic gynecologic surgery
Conditions
Interventions
LB group (liposomal bupivacaine plus bupivacaine group):Preoperative anterior quadratus lumborum block with 133mg liposomal bupivacaine (Jiangsu Hengrui, China) plus 37.5 mg bupivacaine diluted to
BD group (bupivacaine plus dexamethasone group):Preoperative anterior quadratus lumborum block with 37.5 mg bupivacaine plus 4 mg dexamethasone diluted to 20ml on each side.
Sponsors
Xishan People’s Hospital of Wuxi City
Eligibility
Sex/Gender
Female
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1) ASA class I-III; 2) Aged >=18 years; 3) BMI 18.5~30 kg/m^2; 4) Patients undergoing laparoscopic gynecological surgery.
Exclusion criteria
Exclusion criteria: 1) History of allergy to local anesthetic drugs or any of the experimental medications; 2) Cognitive dysfunction; 3) Severe cardiac , pulmonary ,liver or kidney dysfunction; 4) Abnormal coagulation function ; 5) History of chronic pain or preoperative use of sedatives or analgesics.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Oxycodone consumption during first 48 h postoperatively; | — |
Secondary
| Measure | Time frame |
|---|---|
| NRS scores at different time after surgery;The duration of analgesia;Oxycodone consumption at various postoperative periods;Postoperative adverse effects;Area under the curve of pain scores during 0-72 hours postoperatively(AUC NRS 0-72);Opioid-free state during 0-72 hours postoperatively;Patient satisfaction; | — |
Countries
China
Contacts
Public ContactYunhui Zhang
Xishan People’s Hospital of Wuxi City
Outcome results
None listed