Fractures or bone and joint lesions
Conditions
Interventions
Control group:Conventional anesthesia induction and maintenance (anesthesia induction with intravenous injection of midazolam 0.05mg/kg, propofol 2mg/kg, sufentanil 0.3 µ g/kg, cisatracurium 0.15mg/kg
Esmolol group:On the basis of control group, anesthesia induction and maintenance periods were added respectively with intravenous injection of esmolol (0.5mg/kg) and pump injection of esmolol (30 µ g
Sponsors
Tengzhou Central People's Hospital
Eligibility
Sex/Gender
All
Age
30 Years to 80 Years
Inclusion criteria
Inclusion criteria: 80 patients aged 30-80 years, ASA I-II grade, who underwent orthopedic surgery under general anesthesia, signed informed consent forms before surgery.
Exclusion criteria
Exclusion criteria: Exclude patients with cardiovascular, respiratory, neurological, and psychiatric disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood pressure and heart rate values;Blood glucose level;Blood cortisol level;Interleukin-1ß;Interleukin-6;Interleukin-8;Interleukin-10;TNF-a; | — |
Secondary
| Measure | Time frame |
|---|---|
| Patients' total anesthesia dosage;Incidence of adverse reactions in patients;Intraoperative bleeding volume of patients;Postoperative recovery time of patients;Duration of surgery; | — |
Countries
China
Contacts
Public ContactZhang mingyang
Tengzhou Central People's Hospital
Outcome results
None listed