Quality of anesthesia recovery
Conditions
Interventions
NMBA Group(Experiment 1):cisatracurium 0.1mg/kg
Compare Group(Experiment 1):0.9% normal saline solution with equivalent volume of cisatracurium in the NMBA group
A1 Group(Experiment 2): Propofol 3.0 µg/mL TCI + Alfentanil 5 ug/kg
A2 Group(Experiment 2): Propofol 2.5 µg/mL TCI + Alfentanil 10 ug/kg
A3 Group(Experiment 2): Propofol 2.0 µg/mL TCI + Alfentanil 15 ug/kg
Sponsors
Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Age range: 18-65 years old; ASA Grading I-II; Proposed day hysteroscopic surgery under general anesthesia; No other serious systemic comorbidities; Conscious and able to cooperate with examination and treatment; Patient informed consent, and signed written informed consent.
Exclusion criteria
Exclusion criteria: 1. Those who are allergic to the drugs used in this study, such as alfentanil, fentanyl, sufentanil, propofol, etc.; 2. Perennial alcohol craving, long-term use of drugs that affect mental state (such as sedatives) and monoamine oxidase inhibitors; 3. ASA classification greater than grade II; 4. Patients with severe liver dysfunction (such as Child-Pugh class C) or abnormal renal function (such as preoperative dialysis); 5. Arrhythmia, preoperative left ventricular ejection fraction less than 30%, sick sinus syndrome, severe sinus bradycardia (< 50 beats/min) or grade II or above atrioventricular block, with pacemaker installed; 6. Cognitive impairment due to mental and psychological disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VAS score of intraoperative body movement(Experiment 1);Duration from completion of surgery to Aldrete score = 9(Experiment 2); | — |
Secondary
| Measure | Time frame |
|---|---|
| Anesthesia induction time(Experiment 1);Time for insertion of laryngeal mask(Experiment 1);Airway pressure before inflation when laryngeal mask is inserted(Experiment 1);Airway pressure after inflation when laryngeal mask is inserted(Experiment 1);Patient's depth of sedation after surgery(Experiment 2);Time from completion of surgery to removal of laryngeal mask(Experiment 2);Incidence of intraoperative hypotension(Experiment 2);Incidence of bradycardia during surgery(Experiment 2);Postoperative recovery quality(Experiment 2); | — |
Countries
China
Contacts
Public ContactJianjun Li
Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University
Outcome results
None listed