diarrhea-predominant irritable bowel syndrome&
Conditions
Interventions
SSG Group:Sishen granules 5g/ packet, 1 packet each time, once a day for 2 weeks.
Placebo group:Placebo was administered 1 packet once a day for 2 weeks
Sponsors
Tianjin Xiqing Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Age 18-75 years old; (2) Meet the diagnostic criteria of IBS-D and FDr; (3) TCM syndrome differentiation is spleen-kidney Yang deficiency syndrome; (4) The general situation is good; Within 3 months, the blood, urine, stool routine (-), liver and kidney function was normal. (5) The subject fully understands the research content and signs the informed consent.
Exclusion criteria
Exclusion criteria: (1) Previously diagnosed celiac disease, inflammatory bowel disease, bowel cancer or bowel resection, other gastrointestinal diseases that cause diarrhea, unexplained weight loss, or rectal bleeding; (2) The use of probiotic supplements, intestinal adsorbents, slow-release drugs, analgesics or powerful opioids; (3) Patients receiving stable doses of antidepressants for less than 6 weeks; (4) Pregnant women, lactating women or women of childbearing age who have fertility requirements; (5) Mental patients, or cognitive dysfunction; (6) Patients with active infections, inflammatory diseases, hematological disorders and/or malignancies, and chronic kidney and liver diseases; (7) Drug allergy; (8) History of alcohol or drug abuse; (9) The investigator considers that there are other circumstances that are not suitable for participation in the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Abdominal pain daily response;Daily response to diarrhea;The Patient Health Questionnaire 12 Somatic Symptom scale;Evaluation of Traditional Chinese Medicine Syndrome Efficacy; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood routine examination;Urine routine ;Liver function test;Kidney function test;Stool consistency and frequency;Abdominal distension and urgency score;IBS symptom severity scale;Irritable Bowel Syndrome-Quality of Life Measure; | — |
Countries
China
Contacts
Public ContactLi Hai
Tianjin Xiqing Hospital
Outcome results
None listed