diabetic foot ulcers
Conditions
Interventions
GLP-1RA(Liraglutide) therapy group:Routine dressing change is performed every 3 days, and GLP-1RA gel (liraglutide) is applied externally every day at a dose of 2ug/cm2/day
GLP-1RA(Loxenatide) therapy group:Routine dressing change every 3 days, and GLP-1RA gel (Losenatide) for external use every 7 days, with a dose of 1ug/cm2/week
Control group:Routine dressing change every 3 days
Sponsors
Tongji Hospital, Tongji Medical College ,Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. T2DM patients meet the diagnostic criteria of WHO1999; 2. DFU classification adopts Wagner I-II level; 3. Age over 18 years old; 4. The first-line routine treatment of diabetes wound did not heal for 4 weeks.
Exclusion criteria
Exclusion criteria: 1. DKA and hyperosmolar patients; 2. Patients with lower limb arterial occlusion or ABI<0.60; 3. Foot infection PEDIS grading 3-4; 4. Combine patients with severe coronary heart disease, cerebral infarction, heart failure, and renal failure; 5. Patients with malignant tumors, medullary thyroid carcinoma, and pancreatitis; 6. Patients with severe gastrointestinal diseases 7. using immunosuppressants; 8. Pregnant and lactating women. 9. Patients currently participating in other clinical trials; 10. Researchers believe that other reasons are not suitable for clinical trial participants.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Wound area; | — |
Secondary
| Measure | Time frame |
|---|---|
| capillary density;DFU treatment score;Regeneration degree of epidermis and granulation tissue; | — |
Countries
China
Contacts
Public ContactShao Shiying
Tongji Hospital, Tongji Medical College ,Huazhong University of Science and Technology
Outcome results
None listed