Moyamoya disease
Conditions
Interventions
Control group (traditional operation group):Traditional preoperative evaluation methods were used to guide the operation
Trial group (Individualized surgical protocol):Individualized surgical plan based on multimodal evaluation
Sponsors
Huashan Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) Age 18-80 years old; 2) It meets the diagnostic criteria of intracranial large blood vessel occlusion and the indications of blood flow reconstruction surgery; 3) According to the DSM-5 criteria, confirm the diagnosis of vascular cognitive impairment (VCI) and mild VCI (VMCI) according to the Chinese Guidelines for Diagnosis and Treatment of Vascular Cognitive Impairment (2024 edition); 4) Sign informed consent;
Exclusion criteria
Exclusion criteria: 1) There are other diseases and medications that may affect cognitive function; 2) accompanied by other neurological and psychiatric diseases; 3) Study participants who are ineligible for MRI and nuclide examination and have diseases that prevent safe implantation; 4) Pregnant women, breastfeeding women, women of childbearing age who plan to become pregnant or do not have safe contraception; 5) There is a systemic disease that may affect the safety and compliance of study participants and the assessment of physical condition in the tria; 6) Study participants who have participated in, or are currently participating in, other experimental treatments that the principal investigator believes may create confusion; 7) Study participants with a history of stimulant drug abuse, severe liver and kidney dysfunction, coagulopathy, or autoimmune disease that may require long-term steroid or immunosuppressive therapy; 8) Other situations in which the investigator deems it inappropriate to participate in the study;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Perioperative safety evaluation;Perioperative safety evaluation;Perioperative safety evaluation;Postoperative imaging evaluation;Postoperative cognitive function evaluation; | — |
Countries
China
Contacts
Public ContactYing Mao
Huashan Hospital, Fudan University
Outcome results
None listed