postoperative pulmonary complications
Conditions
Interventions
Control :A loading dose of saline was pumped for 10 min before induction of anesthesia (at a rate equivalent to dexmedetomidine 0.6 µg/kg), and after the loading dose, saline was continuously infused
A:A loading dose of saline was pumped for 10 min before induction of anesthesia (at a rate equivalent to dexmedetomidine 0.6 µg/kg), and after the loading dose, saline was continuously infused (at a r
B:A loading dose of dexmedetomidine 0.6 µg/kg was pumped for 10 min before induction of anesthesia, and dexmedetomidine 0.5 µg/kg/h was continuously infused after the loading dose, and the input was s
AB:A loading dose of dexmedetomidine 0.6 µg/kg was pumped for 10 min before induction of anesthesia, and dexmedetomidine 0.5 µg/kg/h was continuously infused after the loading dose, and the input was
Sponsors
The Fourth Hospital of Hebei Medical University
Eligibility
Sex/Gender
All
Age
50 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Age > 50 years; 2. Undergoing elective abdominal surgery with an expected operative time > 2 hours; 3. Modified Frailty Index (mFI) >= 0.21.
Exclusion criteria
Exclusion criteria: 1. ASA > ?; 2. Body mass index (BMI) over 30 kg/m2; 3. Those who are already undergoing mechanical ventilation before surgery; 4. Allergic to dexmedetomidine; 5. Sick sinus syndrome, or severe sinus bradycardia (< 50 beats/minute), or second degree or higher atrioventricular block; 6. Preoperative inability to communicate due to language barriers, mental disorders, and so on; 7. Have already been enrolled in this study; 8. Refused to participate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of pulmonary complications within 7 days after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to postoperative pulmonary complications;ICU admissions;ICU hours;Length of postoperative hospitalization;Composite complication index within 7 days after surgery;Incidence of single or pulmonary complications within 30 days of surgery;Incidence of multiple pulmonary complications within 30 days of surgery;Incidence of extrapulmonary complications within 30 days after surgery;Composite complication index within 30 days after surgery;All-cause mortality within 30 days of surgery; | — |
Countries
China
Contacts
Public ContactHuiqun Jia
The Fourth Hospital of Hebei Medical University
Outcome results
None listed