sepsis-iuduced cardiomyopathy
Conditions
Interventions
Experimental group:On the basis of conventional treatment for sepsis, intravenous infusion of 100 ml of omega-3 polyunsaturated fatty acid-containing Yuen once a day.
Sponsors
Department of Critical Care Medicine, Mindong Hospital of Fujian Medical
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: Conformance to the diagnostic criteria of the "Chinese Guidelines for Emergency Treatment of Sepsis/Septic Shock (2018)" and presence of one or more of the following characteristics of myocardial injury (a. ventricular dilation b. LVEF = 10% c. ventricular diastolic dysfunction d. increased myocardial injury markers e. poor response to fluid resuscitation and catecholamines f. new onset arrhythmias); age >= 18 years; patient or guardian has signed an informed consent form.
Exclusion criteria
Exclusion criteria: (1) Age <18 years old; (2) Pregnant or lactating women; (3) History of pre-existing cardiac dysfunction or acute heart disease not related to sepsis (congenital heart disease, valvular heart disease, acute myocardial infarction, myocarditis, post-cardiopulmonary resuscitation, etc.); (4) Patients participating in other clinical trials; (5) Refusal to sign the informed consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 28-day mortality rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Left ventricular ejection fraction(LVEF%);malonaldehyde,MDA;glutathione peroxidase 4,GPX4;Vasoactive drugs;Hypersensitive troponin I;N-Terminal Pro-Brain Natriuretic Peptide; | — |
Countries
China
Contacts
Public ContactHuogen Lliu
Department of Critical Care Medicine, Mindong Hospital of Fujian Medical University, Fuan, Fujian
Outcome results
None listed