Relative bioavailability
Conditions
Interventions
R-T group:Test sample A is taken in the first cycle, and after a washout period of 5-12 days, test sample B is taken in the second cycle
Sample A is one of liposomes ß nicotinamide mononucleotide and common ß nicotinamide mononucleotide, and sample B is another of liposome ß nicotinamide mononucleotide and ß ordinary nicotinamide monon
T-R group:Test sample B is taken in the first cycle, and after a washout period of 5-12 days, test sample A is taken in the second cycle
Sponsors
The First People's Hospital of Kunshan
Eligibility
Sex/Gender
Male
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Male aged 18 - 45 years old (including boundary value); 2. Body mass index (BMI) 19.0 kg/m^2 – 28.0 kg/m^2 (including cut-off value); 3. Sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Those with serious diseases of the heart, liver, kidney, and hematopoietic system, and patients with mental illness; 2. Those with hypoglycemia; 3. Those who need to take drugs during the trial; 4. Those who have suffered from clinically significant major diseases or undergone major surgical operations within 3 months before screening, or those who plan to undergo surgery during the study period; 5. Those who are addicted to alcohol or those who cannot abstain from alcohol during the test; 6. Smokers or those who cannot stop smoking during the test; 7. Those who have used any drugs (including prescription drugs, over-the-counter drugs, traditional Chinese medicines, etc.) within 2 weeks before screening; 8. Those who cannot tolerate venipuncture or have a history of fainting blood or needle sickness; 9. Those who have a history of drug abuse or have used drugs; 10. Poor compliance in the opinion of the investigator, or any other situation in the opinion of the investigator that the subject is not suitable to participate in this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ß - nicotinamide mononucleotide;Maximum blood concentration;Area under the curve; | — |
Secondary
| Measure | Time frame |
|---|---|
| Peak time;Half-life; | — |
Countries
China
Contacts
Public ContactChen Yafang
The First People's Hospital of Kunshan
Outcome results
None listed