None listed
Conditions
Interventions
Test group:Accept the addition of omega-3 triglyceride parenteral nutrition supplements
Control group:Accept conventional parenteral nutrition preparations
Sponsors
The First Hospital of Lanzhou University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Patients must meet all of the following inclusion criteria to be eligible for this study: 1. Age >= 18 years old and <= 80 years old, gender is not limited; 2. Pathologically diagnosed with colorectal cancer without distant metastasis, and elective radical surgery; 3. Operational nutrition screening, which is expected to require parenteral nutrition support at least 5 days after surgery; 4. American Society of Anesthesiologists (ASA) grade I-III; 5. The patient or his/her family members sign the informed consent form.
Exclusion criteria
Exclusion criteria: Patients cannot be enrolled if they meet any of the following criteria: 1. Allergies to omega-3 triglycerides or other pharmaceutical ingredients (such as egg or soy protein, peanut protein, or other ingredients in the prescription); 2. Severe malnutrition (such as body mass index < 18.5kg/m2 or serum albumin <30 g/L) before surgery; 3. Those who received enteral or parenteral nutrition therapy within 7 days before surgery; 4. Combined with severe dysfunction of important organs such as heart, liver, and kidney; 5. Immune system disease or is receiving immunosuppressive therapy, or has undergone splenectomy; 6. Pregnant or lactating women; 7. Patients with mental disorders or unable to cooperate with treatment and follow-up; 8. Patients with general intravenous infusion contraindications, electrolyte and fluid balance disorders, and metabolic disorders (including protein metabolism disorders, lipid metabolism disorders, and hyperglycemia that does not respond to a 6 unit insulin/hour dose) during the screening period; 9. Serious complications (such as hemorrhagic shock, acute single or multi-organ dysfunction, etc.) during the operation; 10. Other factors that the investigator considers unsuitable to participate in this experiment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Nutritional indicators: serum albumin, prealbumin, transferrin;;Inflammation-related indicators: C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-a (TNF-a), interleukin-1ß (IL-1ß), interleukin-8 (IL-8);; | — |
Secondary
| Measure | Time frame |
|---|---|
| Nutritional indicators: retinol binding protein, nitrogen balance, body mass index, triceps skinfold thickness, and mid upper arm muscle circumference;Immune function indicators: T lymphocyte subsets, immunoglobulin levels, blood routine;Clinical indicators: postoperative hospital stay, incidence of postoperative complications (bleeding, infection, incidence of intestinal fistula);Recovery indicators: recovery time of bowel sounds, first bowel movement time; | — |
Countries
China
Contacts
Public ContactZhu Xiaoliang
The First Hospital of Lanzhou University
Outcome results
None listed