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The Correlation Analysis of Serum ß2M and SPP1 Expression Levels with Disease Activity and Pain Severity in Rheumatoid Arthritis: A Multi-center, Cross-sectional Study

The Correlation Analysis of Serum ß2M and SPP1 Expression Levels with Disease Activity and Pain Severity in Rheumatoid Arthritis: A Multi-center, Cross-sectional Study

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500096783
Enrollment
Unknown
Registered
2025-02-06
Start date
2025-03-01
Completion date
Unknown
Last updated
2025-02-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Inflammatory pain,rheumatoid arthritis

Interventions

Sponsors

The Affiliated Hospital of Xuzhou Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Participants are aged 18 years or older and meet the diagnostic criteria of the 2010 ACR/EULAR classification criteria for RA. 2. Participants are willing to participate in the study and sign the informed consent form. 3. The measurement results of ß2M and SPP1 expression levels in participants' serum samples are available. 4. Participants have sufficient clinical data, including assessments of rheumatoid arthritis disease activity and pain severity.

Exclusion criteria

Exclusion criteria: 1. Participants are under the age of 18. 2. Participants have not been diagnosed with rheumatoid arthritis. 3. Participants refuse to participate in the study or do not sign the informed consent form. 4. The measurement results of ß2M and SPP1 expression levels in participants' serum samples are unavailable. 5. Participants lack sufficient clinical data to assess rheumatoid arthritis disease activity and pain severity. 6. Participants have concurrent severe diseases, such as cancer or autoimmune diseases, that may affect the interpretation of the study results.

Design outcomes

Primary

MeasureTime frame
serum ß2M;serum SPP1;Numeric Rating Scale,NRS;Disease Activity Score 28;Rheumatoid Arthritis Disease Activity Index;

Countries

China

Contacts

Public ContactWen Zhu

Department of Pain Medicine, Affiliated Hospital of Xuzhou Medical University

inoct@126.com+86 135 0521 3661

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026