Disturbance of consciousness
Conditions
Interventions
Group A:Capsaicin was applied to the external auditory canal in the first month and Vaseline was applied to the external auditory canal in the second month
Group B:Vaseline was applied to the external auditory canal in the first month and capsaicin was applied to the external auditory canal in the second month.
Sponsors
Affiliated Hospital of Shandong Second Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. The participant or the authorized representative agrees and signs the informed consent form. 2. All participants have brain damage caused by hypoxia and ischemia. 3. Participants are determined to have chronic disorders of consciousness by at least five evaluations using the Coma Recovery Scale-Revised (CRS-R) (A1 90%, no signs of septic shock, no organ failure). 6. No history of capsaicin allergy.
Exclusion criteria
Exclusion criteria: 1. Organic lesions in the swallowing organs (organic lesions in the mandible, lips, tongue, soft palate, throat, esophagus and other organs); 2. Participants who were intolerant to capsaicin in the past and did not see improvement after treatment (such as irritation symptoms such as allergies); 3. During the grand seizure, mania and other mental symptoms that can not cooperate with the program; 4. High fever or vital signs unstable; 5.Rupture of the external ear canal; 6. otitis media.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Standardized swallowing assement; | — |
Secondary
| Measure | Time frame |
|---|---|
| Vide of uoroscopic swallowing study;Fiberoptic endoscopic examination of swallowing;Surface electromyography;Ultrasonography;Functional magnetic resonance imaging;Brainstem auditory evoked potential;Near-infrared functional brain imaging;Substance P; | — |
Countries
China
Contacts
Public ContactYali Li
Affiliated Hospital of Shandong Second Medical University
Outcome results
None listed