Colorectal disease
Conditions
Interventions
Experimental Group:Nalbuphine 0.4mg/kg was added to the postoperative patient-controlled intravenous analgesia pump
Control Group:Nalbuphine injection was not added to the postoperative patient-controlled intravenous analgesia pump
Sponsors
Chengdu Seventh People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1) aged 18-75 years old; 2) patients undergoing elective laparoscopic colorectal surgery; 3) ASA grade I-III;
Exclusion criteria
Exclusion criteria: 1) patients with previous gastrointestinal surgery; 2) patients who were converted to open surgery; 3)BMI > 30 kg/m^2; 4) patients with a history of radiotherapy/chemotherapy within 14 days before surgery; 5) patients who received gastrointestinal prokinetic drugs within 24 hours before surgery; 6) severe liver and kidney dysfunction (severe liver dysfunction refers to alanine aminotransferase (ALT) or aspartate aminotransferase (AST) more than 2 times the upper limit of normal; Severe renal insufficiency defined as glomerular filtration rate (GFR) < 30 mL/min); 7) pregnant/lactating patients; 8) allergy to study drug or opioid dependence; 9) participants who were enrolled in other interventional clinical trials within 3 months before dosing and/or planned to participate in the trial during the study period;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of gastrointestinal dysfunction within 72 hours after surgery (defined as I-FEED score >=6); | — |
Secondary
| Measure | Time frame |
|---|---|
| I-FEED score at 24h, 48h, and 72h after surgery;Time to first flatus after operation (h);First postoperative defecation time (h);Time to first oral feeding after surgery (h);NRS scores at 24h, 48h and 72h after operation, the number of patient-controlled infusion and the number of rescue analgesia were recorded;RASS sedation score at 24h, 48h and 72h after surgery;Occurrence of adverse drug reactions;Postoperative hospital stay (d); | — |
Countries
China
Contacts
Public ContactHui Zhong
Chengdu Seventh People's Hospital
Outcome results
None listed