The Effects of Low-Dose Esketamine Combined with Dexmedetomidine for Intravenous Patient-Controlled Analgesia on Sleep and Pain After Cesarean Section: A Randomized, Double-Blind Controlled Trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2500096770

Enrollment

Unknown

Registered

2025-02-06

Start date

2025-02-19

Completion date

Unknown

Last updated

2025-02-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

sleep

Interventions

Control group:Sufentanil used in analgesia pump

Esketamine group:The use of sufentanil and esketamine in analgesic pump

Esketamine combined with dexmedetomidine group:Sufentanil, esketamine and dexmedetomidine were used in the analgesia pump

Eligibility

Sex/Gender

Female

Age

20 Years to 45 Years

Inclusion criteria

Inclusion criteria: The included women were full-term singleton pregnancies, underwent cesarean section, had no history of drug allergy, ASA I-II, and were 20-45 years old

Exclusion criteria

Exclusion criteria: Patients with severe systemic diseases, gestational diabetes mellitus, hypertension, drug-related contraindications, mental disorders, communication or mental disorders, opioid, sedative hypnotic, psychiatric drug allergies or drug abuse history, preoperative heart rate<50 beats/min or systolic blood pressure<100 mm Hg before anesthesia were excluded

Design outcomes

Primary

Measure	Time frame
Sleep quality;	—

Secondary

Measure	Time frame
pain;Adverse reaction;Anxiety and depression score;Sedation score;	—

Countries

China

Contacts

Public ContactXie Ying

Beijing Anzhen Nanchong Hospital of Capital MedicalUniversity&Nanchong Central Hospital

475153895@qq.com+86 159 8377 6950

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026