Skip to content

The half effective dose of fospropofol disodium combined with sufentanil to inhibit the cough reaction in patients with weak tracheotomy undergoing tracheal intubation replacement

The half effective dose of fospropofol disodium combined with sufentanil to inhibit the cough reaction in patients with weak tracheotomy undergoing tracheal intubation replacement

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500096769
Enrollment
Unknown
Registered
2025-02-06
Start date
2025-02-17
Completion date
Unknown
Last updated
2025-02-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Tracheotomy reoperation patients

Interventions

Experimental group:The dose of disodium phosphate propofol in the first case was 10 mg/kg, and the difference between adjacent doses was 1/5 of the initial dose, i.e. 2 mg/kg. The tube was changed 5 m

Sponsors

Sichuan Bayi Rehabilitation Center (Sichuan rehabilitation hospital)
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 74 Years

Inclusion criteria

Inclusion criteria: 1.the age ranged from 18 to 74 years old; 2. ASA grade IV; 3. the modified frailty index (MFI) score was >=3; 4. all operations were performed under general anesthesia.

Exclusion criteria

Exclusion criteria: 1. have a history of allergy to analgesic or sedative drugs; 2. have a history of using benzodiazepines in the past month; 3. complicated with myasthenia gravis; 4. uncontrolled grade 3 hypertension; 5. fever or uncontrolled pulmonary infection.

Design outcomes

Primary

MeasureTime frame
bucking;MAP;HR;

Secondary

MeasureTime frame
Pain;Onset time of anesthesia;

Countries

China

Contacts

Public ContactZhao Zeyu

Sichuan Bayi Rehabilitation Center (Sichuan rehabilitation hospital)

gyzhaozy@163.com+86 180 1131 0198

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026