Breast Cancer
Conditions
Interventions
Group A:Anesthetic Induction: 0.2-0.3 mg/kg Remifentanil, 0.4-0.5 µg/kg Sufentanil, and 0.15 mg/kg Cisatracurium administered intravenously
endotracheal intubation after achieving an appropriate depth of anesthesia
maintaining BIS values (45-55), PETCO2 (partial pressure of carbon dioxide in end-tidal breaths) between 35-45 mmHg, and 100% oxygen concentration during surgery.
Anesthetic Maintenance: Inhalation o
Group B:Anesthetic Induction: 0.2-0.3 mg/kg Remifentanil, 0.4-0.5 µg/kg Sufentanil, and 0.15 mg/kg Cisatracurium administered intravenously
maintaining BIS values (45-55), end-tidal carbon dioxide partial pressure (PETCO2) between 35-45 mmHg, and 100% oxygen concentration during surgery.
Anesthetic Maintenance: Inhaled Sevoflurane mainta
intermittent intravenous administration of Cisatracurium during surgery.
Control Group:Anesthetic Induction: 0.2-0.3 mg/kg Remifentanil, 0.4-0.5 µg/kg Sufentanil, and 0.15 mg/kg Cisatracurium administered intravenously
maintaining BIS values (45-55), PETCO2 (partial pressure of end-tidal carbon dioxide) between 35-45 mmHg, and 100% oxygen concentration during surgery.
Anesthetic Maintenance: Inhalation of Sevoflura
Sponsors
Zaozhuang Municipal Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Age is greater than or equal to 18 years old 2. Pathological examination confirmed breast cancer 3. American Society of Anesthesiologists (ASA) classification grades 1-3 4. Patients and their families have no communication and cognitive barriers, informed consent to this study
Exclusion criteria
Exclusion criteria: 1. Patients with gastrointestinal diseases, severe cardiovascular and respiratory system diseases, liver or kidney diseases 2. Individuals with a history of motion sickness or fainting at the sight of needles 3. Those who refuse to cooperate 4. Patients experiencing nausea or vomiting before surgery 5. Individuals allergic to the medications used in this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| (1)PONV:(T1)PACU(T2)0-8h(T3)8-24h(T4). (2)3PONV ,( 0 ~ 3 ) ( 4 ~ 6 ) ( 7 ~ 10) PONV .;Statistics on the grading of PONV in three groups of patients; | — |
Secondary
| Measure | Time frame |
|---|---|
| Evaluate the maximum agitation score during the patient's awakening period using the Ricker Sedation-Agitation Scale, and record the incidence of agitation during the patient's awakening period.;Postoperative sedation effects were evaluated using Ramsay scores at 2, 6, 12, and 24 hours after surgery.;Anesthesia recovery time (recovery of spontaneous breathing, eye opening, recovery of orientation, and tracheal tube removal time); | — |
Countries
China
Contacts
Public ContactZhao Shu
Zaozhuang Municipal Hospital
Outcome results
None listed