Alzheimers disease
Conditions
Interventions
True stimulus group:rTMS intervention was received 5 times a week, with 1 stimulation a day and 2 days of rest for 4 consecutive weeks. The true stimulation group completed iTBS stimulation.
False stimulus group:Patients in the false stimulation group were "intervened" with the same coil as those in the true stimulation group, the coil was placed on the patients scalp, and the stimulation
normal control:None.
Sponsors
Jianyang City People's Hospital
Eligibility
Sex/Gender
All
Age
50 Years to 85 Years
Inclusion criteria
Inclusion criteria: AD: 1. It met the diagnostic criteria for AD of NIA-AA in 2011; 2. Progressive memory function or other cognition that has been objectively reported for more than 6 months by the caregiver or the patient himself declined and the onset of disease was hidden. 3. Neuropsychological scale: simultaneous cognitive or behavioral impairment in at least two areas, significant decline in daily living ability, and may be accompanied by mental behavior abnormalities; Hachinski ischemia score =27 points, MoCA>=26 points, CDR=0 points; Subjects have no memory loss or other cognitive areas of decline, and no psychiatric or neurological disorders; Skull MR Imaging showed no abnormal signs, signed the informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with other types of dementia (such as vascular dementia, Parkinson's disease dementia, frontotemporal dementia, Lewy body dementia, chronic alcoholic encephalopathy, neurosyphilis, normal intracranial pressure hydrocephalus, progressive nucleus Superior ophthalmoplegia, multiple system atrophy, etc.); 2. Pseudo dementia caused by mental illnesses such as severe anxiety and depression 3. Medical history of intracranial tumor, epilepsy, intracranial infection, brain trauma, brain surgery, etc. 4. thyroid function Abnormal energy, folic acid and vitamin B12 deficiency, severe anemia, etc. 5. There is an implanted pacemaker or drug in the body Pump, vagus nerve stimulator or deep brain stimulator; 6. Difficulty in completing neuropsychological assessment; MRI examination and follow-up treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Resting state function Nuclear magnetic function;Global cognitive function;Blood biomarkers;Hematoproteomics; | — |
Secondary
| Measure | Time frame |
|---|---|
| Psychiatric symptom;Memory function;Attention function;Visuospatial function;Language function;Executive function;Genomics;Hematomeboomics;Hematology transcriptomics; | — |
Countries
China
Contacts
Public ContactZhengxi Song
Jianyang City People's Hospital
Outcome results
None listed